After nine weeks of fast and frenetic EPL action, there are only two points separating the top five teams on the ladder.
The game of the round comes last, as 5th-placed Spurs welcome the ladder-leading Citizens to Wembley.
Before this, a cracking mid-table match-up will take place as Brighton and Wolverhampton go head-to-head.
And there's yet another London derby to look forward to, as Crystal Palace attempt to repel an Arsenal side who can't stop winning.
Brighton and Hove Albion v Wolverhampton Wanderers
EPL Odds: Brighton $3.10 / Draw $3 / Wolves $2.50
Two clubs that will know each other well from their Championship days will now do battle in the top league, as Wolverhampton travel to the South Coast to take on Brighton.
The Wanderers have been uber-impressive since their promotion, and some pundits are going as far as to say that they might be the best newly-promoted side of all time.
Usually sides that earn promotion have to grind and toil for every point, in the quest to stay up in the lucrative premier league.
The Wolves however are playing inspired football under Nuno, creating chance after chance in attack.
Their Portuguese midfield duo of Ruben Neves and Joao Moutinho exude class on the ball, while defenders Matt Doherty and Jonny have been superb in the more attacking wing-back positions.
They will be looking to bounce back after last week's loss to Watford, and continue their charge towards the top six.
However, coming up against the Seagulls away from home won't be an easy task, as Amex Stadium is a notoriously tricky place to get all three points in the EPL.
Despite lacking the squad talent at his counterpart's disposal, Brighton manager Chris Hughton has worked wonders with his side since their promotion in 2017.
That has continued this season, where Brighton are looking solid despite fears by their fans in the off-season that they would be returning to the Championship.
Socceroos goalkeeper Mat Ryan has been superb for the South Coast mob. Last week he had his best game of the season, pulling off a string of sensational saves to keep a clean sheet in Brighton's win over Newcastle.
At the other end of the pitch for the Seagulls is Glenn Murray, the veteran striker who has already netted five times this campaign.
Only Eden Hazard, Sergio Aguero and Pierre-Emerick Aubameyang have scored more goals, demonstrating the class of Murray.
At home, where Brighton have only lost 2 of their last 11 in the EPL, Murray and Co. will be ready to fire.
Key EPL Stat
Wolves have only won 1 of their last 8 games against Brighton: BHA to win or draw @ $1.55
EPL Betting Tip: Total Goals under 1.5 @ $2.70
Reasoning: Both Mat Ryan and Wolves' Rui Patricio are superb goalies for their club as well as country.
Combine this with the fact that showers are forecast for Saturday on the windy south coast and this could be a dour, low-scoring game.
Crystal Palace v Arsenal
EPL Odds: Palace $4 / Draw $3.75 / Arsenal $1.83
In this Sunday afternoon clash, Crystal Palace welcome Arsenal from across the Thames, in what is expected to be a hard-fought London Derby at Selhurst Park.
The Gunners are in the midst of an dominant winning streak, which at the time of writing, spans 10 games in all competitions.
If they can account for Sporting Lisbon in Portugal in the Europa league, they will go into this weekend's EPL fixture with even more confidence.
It's not just the fact that Arsenal are winning game after game, but the manner in which they are doing it.
They are playing champagne football, scoring beautiful goals that were regularly seen in the height of Arsene Wenger's reign.
New gaffer Unai Emery is starting to get the best out of Mesut Ozil, who was once considered amonsgt the best midfielders in the world.
With both Aubameyang and Alexandre Lacazette also scoring for fun, Arsenal have plenty of goals in them.
However, if Crystal Palace have shown anything under Roy Hodgson, it's that they know how to defend.
The Eagles have already kept three clean sheets this campaign, despite the fact that they have only won twice and drawn once.
Mamadou Sakho is an imposing centre-back, outside of which Patrick van Aanholt and young gun Aaron Wan-Bissaka provide an attacking threat from the full back positions.
However, against a team like Arsenal, these full backs will need to be disciplined, making sure they perform their defensive duties first before they think about venturing forward.
If this defence can hold up, Crystal Palace's star man Wilfried Zaha can be damaging on the counter-attack.
But, having said this, you can't back against Arsenal's winning streak.
Key EPL Stat
Arsenal have won their last 10 games in all competitions
EPL Betting Tip: Arsenal to win head-to-head @ $1.83
Reasoning: The form that Arsenal are in, the $1.83 is huge overs.
Tottenham Hotspur v Manchester City
EPL Odds: Spurs $4.33 / Draw $4 / City $1.67
This match could very well decide the nature of Tottenham's season.
Looking all but certain of being knocked out of the Champions League following their 2-2 draw with PSV Eidenhoven midweek, a heavy defeat here could relegate Spurs to another season of almost yet so far.
Mauricio Pochettino has transferred this club from a top six to a title challenging side in his time as manager, yet has no silverware to show for it, much to the frustration of most Spurs fans.
Against a Man City side who haven't conceded in over 360 minutes of football, the task won't be easy for Poch and his side.
The good news from a Spurs perspective is that they welcomed back creator-in-chief Christian Eriksen from injury in the Champions League.
His class on the ball will be crucial in unlocking City's defence, as he aims to link up with Harry Kane.
With Erik Lamela and Lucas Moura also having no trouble finding the back of the net of late, expect Spurs to find a goal or two.
In fact, the North Londeners have scored at least one goal in their last 15 matches.
But if there's one side that's facing no difficulties finding the back of the net, it's Man City.
The Citizens put five past Burnley last week, with five different members of their star-studded attack putting their name on the score sheet.
With Kevin De Bruyne also making his long-awaited return from injury off the bench, the Citizens have multiple avenues to goal.
With Pep Guardiola stamping his trademark and intricate tika-taka style of attacking play on his side, there is no better team to watch in the league than Man City.
And if Tottenham defend like they did against PSV, Hugo Lloris will have a busy night picking the ball out of the back of his net.
Key EPL Stat
In the last 3 encounters between these sides, there have been at least 4 goals scored.
EPL Betting Tip: Total goals to be over 3.5 @ $2.40
Reasoning: Based on how Spurs are defending, Man City alone should cover this number, while Tottenham are also likely to pick-up a goal or two.