To kick off Round 3, newly-promoted Wolves will be battening down the hatches because the all-conquering Citizens are coming to town.
Then, Eddie Howe's Bournemouth will be looking to make it three wins in a row against the visiting Toffees.
But the highlight match of the round sees a confident Tottenham team travel up to Manchester to face a side desperate to redeem themselves.
Wolverhampton Wanderers v Manchester City
EPL action resumes this weekend when defending champions Manchester City travel to the Molinuex to take on newly-promoted Wolverhampton.
Fresh off a 6-1 demolition job on Huddersfield Town, Man City are looking every bit the team that notched up a record-breaking 100 points to take home the title last season.
City veteran Sergio Aguero scored a hat-trick, and looked particularly dangerous playing alongside the future heir to his throne, Gabriel Jesus.
Even though the Citizens will be without star man Kevin De Bruyne for three months, this display suggests that they have more than enough talent to cope.
Wolverhampton meanwhile have splashed the cash on a number of big-name recruits over the past year.
Their squad wouldn't look out of place in the Portuguese Primera Liga, with a number of their key players, as well as their head coach Nuno, hailing from Portugal.
The Wolves have shown signs of promise in their two games in the top flight to date, but still look a few weeks away from gelling as a team and adjusting to the EPL standard.
Against a ruthless City side, the West Midlands outfit could be on the end of a thrashing here.
Key EPL Stat
Of Manchester City's last 8 games in the EPL, 6 have resulted in victories by a margin of 2+ goals.
EPL Betting Tip: Manchester City to win by a margin of 2+ goals @ $1.70
Reasoning: The centurions are looking just as sharp as last campaign, which doesn't bode well for the Wolves here. Another win by 2+ goals is on the cards.
Bournemouth v Everton
This fixture pits 6th against 7th, after both the Cherries and Toffies have had sweet starts to the season.
Bournemouth, under highly regarded head coach Eddie Howe, will be looking to make it three wins in a row here.
Howe is the EPL manager with the longest continuous spell at his club, having taken the reigns of the South Coast side in 2012.
Take away a brief spell with Burnley, and Howe has been with Bournemouth since 2009, steadily improving the club each year.
With a talented squad at his disposal, who are all willing to put in the hard yards for their gaffer, the Cherries are capable of causing one or two big upsets in the 2018/19 season.
Contrasting Bournemouth, Everton have decided that frequently chopping and changing managers and splashing the cash are their avenues to success.
They brought in a number of high class players in the transfer window, including Brazilian winger Richarlison and Colombian centre-back Yerry Mina.
Mina was huge for Colombia at the World Cup, with the 195cm giant heading home three goals.
If he makes his Everton debut this week, he will need to be closely marked at set-pieces by Bournemouth's defenders.
Key EPL Stat
In the EPL, Everton have never defeated Bournemouth at Dean Court (2 losses, 1 draw).
EPL Betting Tip: Bournemouth to win head-to-head @ $2.60
Reasoning: The Cherries are a more cohesive team at the moment, with Marco Silva and Everton still needing some time to iron out the creases.
With the home advantage, they should prove too strong for the Toffees.
Manchester United v Tottenham Hotspur
After Man U's shock loss to Brighton and Hove Albion last week, they will be desperate to respond in front of their home fans.
It was one of the Red Devils' worst performances under Mourinho, in a game where they failed to threaten.
In the 3-2 loss, Man U had 9 shots at goal, with only 3 on target. Tottenham meanwhile had 25 shots on goal, 11 of which were on target in their 3-1 victory over Fulham last week.
While Mourinho has never been known for his attacking football, he will need to get more out of his stars Romelu Lukaku, Paul Pogba and Alexis Sanchez if he wants to avoid back-to-back defeats.
It wasn't just the Red Devils' attack letting them down, with their defence looking far from sturdy.
Mourinho attempted to sign Tottenham centre-back Toby Alderweireld in the transfer window to shore up his defence. But the club seemed unwilling to fork out the requisite cash.
This decision may come back to haunt the Red Devils, after Alderweireld impressed in his return to the Spurs' line-up last week.
Tottenham have started the season by winning both of their fixtures- the first time they have done so in four years.
With Harry Kane also breaking his August goal-drought, the North London side will be heading to Manchester full of confidence to make it three on the trot.
Key EPL Stat
The last 8 clashes between these clubs has been won by the home team.
EPL Betting Tip: Manchester United to win head-to-head @ $2.50
Reasoning: Home ground advantage is always significant in the EPL, and even more so in this fixture.
At Old Trafford, you'd expect Manchester United to put in a redemptive performance against Tottenham, who are typically slow starters to the season.