EPL action returns this weekend after the international break, with a smorgasboard of top-notch fixtures.
Claudio Ranieri returns to the EPL after the miracle he worked with Leicester. This time he's at the helm of Fulham, who will look to start their new era with a win against the struggling Saints.
West Ham are the latest team in the Man City firing line. They will be looking for something special when the Citizens come to town.
And the highlight fixture of the round sees the latest instalment of the always intense London derby between Tottenham and Chelsea.
Fulham v Southampton
EPL Odds: Fulham $2.50 / Draw $3.30 / S'ton $2.70
Anchored to the bottom of the ladder and looking like relegation favourites, something had to change at Fulham.
The now standard quick-fix in the EPL of replacing the coach mid-season was implemented once again.
And who should Fulham appoint but none other than manager-extraordinaire Claudio Ranieri.
This will be the 18th side that the experienced Italian will have managed. But it's what he did at Leicester that has him ranked as one of the greatest.
Ranieri was the mastermind behind Leicester City's unprecedented EPL title, when the bookies had them at 1000/1 at the beginning of the season.
Fulham fans will be hoping he can repeat the miracle during his time in London.
While it's too late for that this season, the first and only item on Ranieri's agenda will be avoiding relegation.
That starts here, with a winnable home game against struggling Southampton.
The Cottagers weren't looking all that bad before Slavisa Jokanovic's dismissal, and were unlucky not to get something out of the 2-0 away defeat to Liverpool.
Aleksandar Mitrovic's goal was incorrectly flagged out for offside. Liverpool then took a quick restart which then led to the opening goal of the game for Mo Salah.
Mitrovic will be eager to get his name on the scoresheet here and help start Ranieri's reign with a win.
Like Fulham, Southampton have only recorded one victory in their 2018/19 EPL campaign.
This sole victory came against Crystal Palace all the way back on the 2nd of September.
Unless the Saints can turn their rotten run of performance around soon, their manager Mark Hughes might be the next gaffer heading for the exit door.
Key EPL Stat
Across all competitions, the Saints are undefeated in their previous 6 encounters with Fulham: Southampton to win or draw @ $1.45
EPL Betting Tip: Fulham to win @ $2.50
Reasoning: Teams usually receive a noticeable boost in their first game under a new manager.
Players want to impress their new boss and that should give Fulham the advantage against a lacklustre Southampton side.
West Ham v Manchester City
EPL Odds: West Ham $11 / Draw $6 / City $1.22
After twelve weeks of competition, Man City are once again looking like the team to beat.
Their glut of world class players who are all buying into Pep Guardiola's philosophy and style makes for a team that appears unbeatable.
That's why, even in a game away from home against a good mid-table team, the Citizens are starting as $1.22 favourites.
In their last four fixtures, the team from Manchester have piled on 17 goals, winning each match by a margin of at least 2+ goals.
Sergio Aguero and David Silva in particular have been playing in near career-best form, in a worrying sign for the Irons.
However, all four of these matches were home games for City. This game in London will be their first away game in nearly a month.
No matter how good you are, winning on the road in the EPL is always a tough ask.
Combine this with the fact that after the international break, funny things sometimes occur.
This is especially true for giants like Man City, whose squad is almost entirely made up by players who featured during the international break.
This is where smaller teams like West Ham have an advantage.
Most of their players would have remained in London during the international break, where they no doubt spent plenty of time analysing and preparing for the Man City clash.
With the benefit of an ex-City player in their squad in Pablo Zabaleta, the Hammers will turn to his experience and unique insider knowledge in preparing for what they know will be a tough task.
With a striker in Marco Arnautovic who is in tremendous form, West Ham aren't without their chance, especially if their opponents don't turn up.
Key EPL Stat
In 3 of their previous 4 EPL away games, the Citizens have scored 1 or fewer goals
EPL Betting Tip: West Ham with a +1.5 goal handicap @ $2.10
Reasoning: While City should be too good, this bet provides some security taking into consideration the potential impact of the international break.
Tottenham v Chelsea
EPL Odds: Spurs $2.70 / Draw $3.30 / Chelsea $2.60
The match of the round takes place on Sunday morning, in what will be a high-stakes and intense London derby.
These are two teams that have always been at each other's throats.
But in recent season's the hatred between these clubs and their supporters has grown to another level, drawing parallel with the North London derby between Spurs and the Gunners.
With Tottenham's continuing stadium fiasco, this game will be played at Wembley, which is expected to draw a bumper crowd for such a crucial clash.
Last time these teams met, Tottenham pulled off a huge 3-1 victory over the Blues.
A brace from Dele Alli and a wonder goal from Christian Eriksen put an end to a horror run of results at Stamford Bridge for the visitors.
If they can reproduce their performance from the Bridge, then Spurs are more than capable of getting the win at home.
The problem for Tottenham though is that they aren't playing that well.
While form tends to go out the window in these big derbies, Chelsea's record under Sarri will have plenty of Spurs fans anticipating the game with dread.
Sarri is yet to taste defeat since taking the helm at the beginning of the season.
His "Sarriball" style of play has rejuvenated the West London side, and in particular, Eden Hazard.
Hazard is back looking like one of the world's best after a mediocre campaign last season.
With left-back Marcos Alonso also posing a genuine attacking threat on the same flank as Hazard, Tottenham's right-side defence will need to be strong.
If it isn't, Sarri and Chelsea will not only extend their undefeated streak, but record a memorable derby victory at Wembley.
Key EPL Stat
The away team has won 7 of Tottenham's last 8 EPL matches: Chelsea to win @ $2.60
EPL Betting Tip: Match to end in a draw @ 3.30
Reasoning: So many of these "Big Six" match-ups have been tight affairs this season.
With Keiren Trippier's injury at right-back, Serge Aurier will likely start for Spurs. While lacking Trippier's threat going forward, Aurier's pace makes him better equipped to deal with Hazard and Alonso.