The match of the round sees two AFC powerhouses facing off, with the result set to have major implications on the post-season.
A loss for either team would see them drop down the seeding ranks and potentially lose touch with the top playoff bracket.
The Steelers will be hoping to avoid back-to-back losses for the first time this season and will feel confident at home, having won three straight at Heinz Field.
Quarterback Ben Roethlisberger is desperate to find some consistency, having completed 66.1% of his passes this season for 3,664 yards, 24 touchdowns and 12 interceptions.
Pittsburgh have conceded an average of 22.3 points per match this season, which is a concern considering the soft draw they've had.
Ben Roethlisberger Source: AAP
For the LA Chargers, this year feels different.
Currently in his 14th season with the franchise, quarterback Philip Rivers finally looks to have a squad capable of bringing out the best in him.
He has completed 69.5% of passes this season for 3,119 yards, 26 touchdowns and 6 interceptions, placing him in MVP contention.
The Chargers are also proving lethal on the ground, averaging 128 yards per match, lead by running back Melvin Gordon.
In more pleasing signs for coach Anthony Lynn, the Rams' defence has been water tight in recent months. They've conceded 19 points or less in six of their last seven games, a key reason why they've lost only once since October.
Expect another big game from the Chargers defensive unit, with Roethlisberger's attacking arsenal to be limited.
LA have played some of their best football on the road this season and they are more than capable of winning this game outright.
Key NFL Betting Statistics
Both Ben Roethlisberger and Philip Rivers were drafted in 2004. In career match-ups, Big Ben holds a 5-2 record over Rivers.
The Steelers are 3-6-1 ATS in their last 10 games when favourite by at least three points.
Free NFL Expert Pick: Chargers with the +3.5 start @ $1.92
Reasoning: The Chargers are one of the form teams of the league and facing off against a rocky Steelers outfit here, take them with the start.